See our Nature Methods Application Note: "High Throughput in vivo screening for anti-angiogenic compounds using the Z-Tag^SM Angiogenesis Assay."

The Z-Tag Acute Toxicity Assay Starter Kit provides a rapid, cost-effective way to evaluate zebrafish acute toxicity screening in your own lab. Experience how easy in vivo acute toxicity screening can be!"

Molecular pathways are highly conserved between zebrafish and humans. Zygogen has analyzed a diverse panel of human genes including: kinases, cytoskeletal proteins, proteases, channel proteins, growth factors, transcription factors, oncogenes, cell-surface receptors, and intracellular signal tranaduction proteins. We find that approximately 80% have zebrafish homologs with an average amino acid identity of 62%.

The Z-Tag Angiogenesis Assay Starter Kit provides a convenient, cost-effective way to implement in vivo angiogenesis compound screening in zebrafish.

Zygogen announces three new compound screening services in zebrafish embryos: Notch Activity Analysis, Cartilage Assessment, and Bone Assessment.

See our recent publication: “Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish” Cancer Research (2007) 67: 11386-11392.

Fisher Scientific Now Offers Zygogen Embryos
Zygogen has joined Fisher’s Third Party Vendor program. This program allows companies to take advantage of their existing Fisher Scientific account to obtain Z-Tag^SM and Morphant^TM zebrafish embryos. Orders can be placed through the Fisher Scientific website or through a Fisher representative. You will be billed through your Fisher account and we will ship your embryo order directly from our facility. Please contact us or a Fisher Scientific representative for more information.  (October 2007)

Zygogen Launches Online Zebrafish Embryo Sales
Zygogen now offers zebrafish embryos for sale to researchers for in-house experimentation without the need for an aquatic facility.  Z-Tag^SM transgenic and Morphant^TM antisense morpholino-injected embryos are available online at www.zygogen.com/products.  Zygogen continues to offer embryo services such as gene knockdown phenotyping and compound screening.  Please see the website for details.  (August 2007)

Zygogen licenses Morphant technology from the University of Minnesota for use in zebrafish. This exclusive license establishes Zygogen as the Commercial provider of target validation studies in zebrafish. (July, 2006)

Zygogen licenses transgenic zebrafish technology, Z-Tag, to UK-based DanioLabs for internal drug discovery. (April, 2006)

Two of Zygogen's disease model assays are approved for screening in NIH's Roadmap Initiative through the MLSCN. Zygogen to participate through a collaboration with the Emory University Screening Center (winter, 2005)